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ea0028p190 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Investigating the sites and mechanisms by which peripheral prokineticin 2 administration reduces food intake and body weight in mice

Beale Kylie , Gardiner James , Bewick Gavin , Hostomska Klara , Patel Neekhil , Hussain Syed , Ebling Francis , Jethwa Preeti , Prosser Haydn , Ghatei Mohammad , Bloom Stephen , Dhillo Waljit

Prokineticin 2 (PK2) is a neuropeptide expressed in hypothalamic nuclei involved in the regulation of energy homeostasis, and has been shown to acutely reduce food intake in rodents. PK2 binds to and activates two G protein-coupled receptors, the PK receptor 1 (PKR1) and the PK receptor 2 (PKR2). We aimed to determine the sites and receptors which mediate the anorectic effects of peripherally administered PK2 within the CNS. We investigated neuronal activity in the hypothalamu...

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Investigating the sites and mechanisms by which peripheral prokineticin 2 administration reduces food intake and body weight in mice

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